George Clooney and Cindy Crawford have made an unlikely pair in a new advertisement released this week.

(PHOTO:Twitter/Marc Gueco pic.twitter.com/TIf8HFCO)George Clooney in Armani and Stacy Keibler in Marchesa

Crawford, who is married to Rande Gerber, appears in bed with Clooney in the campaign promoting a new brand of tequila called Casamigos.

Clooney has been in a high-profile relationship with model Stacey Keibler since 2011.

Despite their respective partners, Crawford and Clooney's video clip for Casamigos has fans talking, but it turns out the celebrities have teamed up in making the drink.

Longtime friends and business partners, Clooney and Gerber created Casamigos together, which loosely translated means "house of friends," according to E! News.

The advert for Casamigos features the "Ocean's 11" star and Crawford, one of the biggest supermodels of all time, together when Gerber enters and asks, "What's going on?" before Crawford pulls the covers over her head. Watch the video on YouTube here.

Clooney and Rande have been good friends "for about 20 years," an insider told Yahoo OMG!

"Those guys like to have a good time, they like to party, so they decided one night that they needed their own house tequila," explained the insider.

This is not the first time the couples have been linked. Over Thanksgiving, Crawford and Gerber were spotted vacationing in Cabo San Lucas, Mexico with Clooney and Keibler.

Meanwhile, Clooney and Keibler may be taking their relationship to the next level. Although the actor is reportedly unwilling to be married again, he and Keibler, a former WWE wrestler, may be getting more serious.

"Stacy is completely head over heels in love with him, and she knew going into the relationship that he wasn't likely to marry her," a source close to the couple, revealed to In Touch Weekly. "But she is really ready to have a child and feels that George would make the perfect father."

While marriage has not been discussed between the two, Clooney and Keibler reportedly had "a talk" about children.

"George brought it up first, but Stacy thinks it's a good idea," the insider told In Touch. "George is constantly telling her how perfect she is for him in every way."

George Clooney and Cindy Crawford have made an unlikely pair in a new advertisement released this week.

(PHOTO:Twitter/Marc Gueco pic.twitter.com/TIf8HFCO)George Clooney in Armani and Stacy Keibler in Marchesa

Crawford, who is married to Rande Gerber, appears in bed with Clooney in the campaign promoting a new brand of tequila called Casamigos.

Clooney has been in a high-profile relationship with model Stacey Keibler since 2011.

Despite their respective partners, Crawford and Clooney's video clip for Casamigos has fans talking, but it turns out the celebrities have teamed up in making the drink.

Longtime friends and business partners, Clooney and Gerber created Casamigos together, which loosely translated means "house of friends," according to E! News.

The advert for Casamigos features the "Ocean's 11" star and Crawford, one of the biggest supermodels of all time, together when Gerber enters and asks, "What's going on?" before Crawford pulls the covers over her head. Watch the video on YouTube here.

Clooney and Rande have been good friends "for about 20 years," an insider told Yahoo OMG!

"Those guys like to have a good time, they like to party, so they decided one night that they needed their own house tequila," explained the insider.

This is not the first time the couples have been linked. Over Thanksgiving, Crawford and Gerber were spotted vacationing in Cabo San Lucas, Mexico with Clooney and Keibler.

Meanwhile, Clooney and Keibler may be taking their relationship to the next level. Although the actor is reportedly unwilling to be married again, he and Keibler, a former WWE wrestler, may be getting more serious.

"Stacy is completely head over heels in love with him, and she knew going into the relationship that he wasn't likely to marry her," a source close to the couple, revealed to In Touch Weekly. "But she is really ready to have a child and feels that George would make the perfect father."

While marriage has not been discussed between the two, Clooney and Keibler reportedly had "a talk" about children.

"George brought it up first, but Stacy thinks it's a good idea," the insider told In Touch. "George is constantly telling her how perfect she is for him in every way."